The impact of volumetric modulated arc radiotherapy on clinical outcomes of patients with gynecological malignancies

Introduction. In locally advanced cancers of the cervix, endometrium and vulva, radiotherapy is primary treatment modality. recent years, new modern techniques external radiation have been developed in oncology, with goal dose escalation to target volume, while sparing healthy tissues. The aim this study determine impact volumetric modulated arc therapy on clinical outcomes patients gynecological malignancies. Material Methods. Data were retrospectively collected from 60 treated for International Federation Gynecology Obstetrics stage I - III cervical, endometrial vulvar cancers, using definitive (n = 35) or adjuvant 25) radiotherapy/ chemoradiotherapy. Thirty underwent three-dimensional conformal (definitive 22 8) other 30 13 17). following outcome parameters compared between two groups: complete response, disease free survival, progression 4-year overall survival. Results. Progression survival chemoradiotherapy was 17.2 months, group it 7.9 months (p 0.300). Four-year who 50%, 61.5% 0.200), radiotherapy/chemoradiotherapy 75% vs. 88.2%, respectively 0.400). Conclusion. Although without statistical significance, showed better results respect previously unoperated radiotherapy/chemoradiotherapy.